Abstract

A Niosome is a non-ionic surfactant-based Vesicle (biology and chemistry). Niosomes are formed mostly by non-ionic surfactant and cholesterol incorporation as an excipient. Other excipients can also be used. Niosomes have more penetrating capability than the previous preparations of emulsions. Niosomes are lamellar structures that are microscopic in size. They constitute of nonionic surfactant of the alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media. The objective of the work is to design niosomes of a drug meant for infections caused due to Gram-positive and Gram-negative bacteria., the objective of the present work is design to formulate and evaluate niosomes of Gatifloxacin for efficient parentral administration in case of Gram-positive and Gram-negative bacteria.